Astrocytes in the retrotrapezoid nucleus sense H + by inhibition of a Kir 4 . 1 - Kir 5 . 1 -
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چکیده
Revised Submission (JN-00544-2010R1) 1 2 3 4 Astrocytes in the retrotrapezoid nucleus sense H by inhibition of a Kir4.1-Kir5.1-like 5 current and may contribute to chemoreception by a purinergic mechanism 6 7 8 Ian C. Wenker*, Orsolya Kréneisz, Akiko Nishiyama, Daniel K. Mulkey 9 10 Department of Physiology and Neurobiology, University of Connecticut, 75 N. Eagleville Rd., 11 Storrs, CT 06269. 12 13 14 Abbreviated title: astrocyte provide a purinergic drive to breathe 15 16
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متن کاملAstrocytes in the retrotrapezoid nucleus sense H+ by inhibition of a Kir4.1-Kir5.1-like current and may contribute to chemoreception by a purinergic mechanism.
Central chemoreception is the mechanism by which CO(2)/pH sensors regulate breathing in response to tissue pH changes. There is compelling evidence that pH-sensitive neurons in the retrotrapezoid nucleus (RTN) are important chemoreceptors. Evidence also indicates that CO(2)/H(+)-evoked adenosine 5'-triphosphate (ATP) release in the RTN, from pH-sensitive astrocytes, contributes to chemoreceptio...
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تاریخ انتشار 2010